The human V delta 2(+) T-cell compartment comprises distinct innate-like V gamma 9(+) and adaptive V gamma 9(-) subsets

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00106544" target="_blank" >RIV/00216224:14740/18:00106544 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/s41467-018-04076-0" target="_blank" >http://dx.doi.org/10.1038/s41467-018-04076-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-018-04076-0" target="_blank" >10.1038/s41467-018-04076-0</a>

Result language
angličtina
Original language name
The human V delta 2(+) T-cell compartment comprises distinct innate-like V gamma 9(+) and adaptive V gamma 9(-) subsets
Original language description
V delta 2(+) T cells form the predominant human gamma delta T-cell population in peripheral blood and mediate T-cell receptor (TCR)-dependent anti-microbial and anti-tumour immunity. Here we show that the V delta 2(+) compartment comprises both innate-like and adaptive subsets. V gamma 9(+) V delta 2(+) T cells display semi-invariant TCR repertoires, featuring public V gamma 9 TCR sequences equivalent in cord and adult blood. By contrast, we also identify a separate, V gamma 9(-) V delta 2(+) T-cell subset that typically has a CD27(hi)CCR7(+)CD28(+)IL-7R alpha(+) naive-like phenotype and a diverse TCR repertoire, however in response to viral infection, undergoes clonal expansion and differentiation to a CD27(lo)CD45RA(+)CX(3)CR1(+) granzymeA/B+ effector phenotype. Consistent with a function in solid tissue immunosurveillance, we detect human intrahepatic V gamma 9(-) V delta 2(+) T cells featuring dominant clonal expansions and an effector phenotype. These findings redefine human delta d T-cell subsets by delineating the V delta 2(+) T-cell compartment into innate-like (V gamma 9(+)) and adaptive (V gamma 9(-)) subsets, which have distinct functions in microbial immunosurveillance.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology

Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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