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Conformational Selection of Dimethylarginine Recognition by the Survival Motor Neuron Tudor Domain

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00101121" target="_blank" >RIV/00216224:14740/18:00101121 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1002/anie.201708233" target="_blank" >http://dx.doi.org/10.1002/anie.201708233</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/anie.201708233" target="_blank" >10.1002/anie.201708233</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Conformational Selection of Dimethylarginine Recognition by the Survival Motor Neuron Tudor Domain

  • Original language description

    Tudor domains bind to dimethylarginine (DMA) residues, which are post-translational modifications that play a central role in gene regulation in eukaryotic cells. NMR spectroscopy and quantum calculations are combined to demonstrate that DMA recognition by Tudor domains involves conformational selection. The binding mechanism is confirmed by a mutation in the aromatic cage that perturbs the native recognition mode of the ligand. General mechanistic principles are delineated from the combined results, indicating that Tudor domains utilize cation-p interactions to achieve ligand recognition.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10402 - Inorganic and nuclear chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Angewandte Chemie International Edition

  • ISSN

    1433-7851

  • e-ISSN

  • Volume of the periodical

    57

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    5

  • Pages from-to

    486-490

  • UT code for WoS article

    000419110500018

  • EID of the result in the Scopus database

    2-s2.0-85042112129