Conformational Selection of Dimethylarginine Recognition by the Survival Motor Neuron Tudor Domain

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00101121" target="_blank" >RIV/00216224:14740/18:00101121 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/anie.201708233" target="_blank" >http://dx.doi.org/10.1002/anie.201708233</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/anie.201708233" target="_blank" >10.1002/anie.201708233</a>

Result language
angličtina
Original language name
Conformational Selection of Dimethylarginine Recognition by the Survival Motor Neuron Tudor Domain
Original language description
Tudor domains bind to dimethylarginine (DMA) residues, which are post-translational modifications that play a central role in gene regulation in eukaryotic cells. NMR spectroscopy and quantum calculations are combined to demonstrate that DMA recognition by Tudor domains involves conformational selection. The binding mechanism is confirmed by a mutation in the aromatic cage that perturbs the native recognition mode of the ligand. General mechanistic principles are delineated from the combined results, indicating that Tudor domains utilize cation-p interactions to achieve ligand recognition.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10402 - Inorganic and nuclear chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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