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RNA methylation in nuclear pre-mRNA processing

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00101444" target="_blank" >RIV/00216224:14740/18:00101444 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1002/wrna.1489" target="_blank" >http://dx.doi.org/10.1002/wrna.1489</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/wrna.1489" target="_blank" >10.1002/wrna.1489</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    RNA methylation in nuclear pre-mRNA processing

  • Original language description

    Eukaryotic RNA can carry more than 100 different types of chemical modifications. Early studies have been focused on modifications of highly abundant RNA, such as ribosomal RNA and transfer RNA, but recent technical advances have made it possible to also study messenger RNA (mRNA). Subsequently, mRNA modifications, namely methylation, have emerged as key players in eukaryotic gene expression regulation. The most abundant and widely studied internal mRNA modification is N-6-methyladenosine (m(6)A), but the list of mRNA chemical modifications continues to grow as fast as interest in this field. Over the past decade, transcriptome-wide studies combined with advanced biochemistry and the discovery of methylation writers, readers, and erasers revealed roles for mRNA methylation in the regulation of nearly every aspect of the mRNA life cycle and in diverse cellular, developmental, and disease processes. Although large parts of mRNA function are linked to its cytoplasmic stability and regulation of its translation, a number of studies have begun to provide evidence for methylation-regulated nuclear processes. In this review, we summarize the recent advances in RNA methylation research and highlight how these new findings have contributed to our understanding of methylation-dependent RNA processing in the nucleus. This article is categorized under: RNA Processing &gt; RNA Editing and Modification RNA Processing &gt; Splicing Regulation/Alternative Splicing RNA Interactions with Proteins and Other Molecules &gt; Protein-RNA Interactions: Functional Implications

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Wiley Interdisciplinary Reviews: RNA

  • ISSN

    1757-7004

  • e-ISSN

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    17

  • Pages from-to

    1489

  • UT code for WoS article

    000447167100001

  • EID of the result in the Scopus database

    2-s2.0-85052365969