Interplays of different types of epitranscriptomic mRNA modifications
Result description
Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m(6)A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m(6)Am, m(5)C, m(1)A and psi and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.
Keywords
Inosinem(6)Am(6)A(m)m(5)Cm(1)ApseudouridineepitranscriptomeADAR
The result's identifiers
Result code in IS VaVaI
Result on the web
https://www.tandfonline.com/doi/full/10.1080/15476286.2021.1969113
DOI - Digital Object Identifier
Alternative languages
Result language
angličtina
Original language name
Interplays of different types of epitranscriptomic mRNA modifications
Original language description
Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m(6)A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m(6)Am, m(5)C, m(1)A and psi and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.
Czech name
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Czech description
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Classification
Type
Jimp - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
LTC18052: Integrative studies of molecular mechanisms of mammalian epitranscriptome
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RNA Biology
ISSN
1547-6286
e-ISSN
—
Volume of the periodical
18
Issue of the periodical within the volume
S1
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
19-30
UT code for WoS article
000687601700001
EID of the result in the Scopus database
2-s2.0-85113759012
Basic information
Result type
Jimp - Article in a specialist periodical, which is included in the Web of Science database
OECD FORD
Biochemistry and molecular biology
Year of implementation
2021