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The role of RNA adenosine demethylases in the control of gene expression

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F19%3A00109891" target="_blank" >RIV/00216224:14740/19:00109891 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S1874939918300439?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1874939918300439?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.bbagrm.2018.12.001" target="_blank" >10.1016/j.bbagrm.2018.12.001</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The role of RNA adenosine demethylases in the control of gene expression

  • Original language description

    RNA modifications are being recognized as an essential factor in gene expression regulation. They play essential roles in germ line development, differentiation and disease. In eukaryotic mRNAs, N-6-adenosine methylation (m(6)A) is the most prevalent internal chemical modification identified to date. The m(6)A pathway involves factors called writers, readers and erasers. m(6)A thus offers an interesting concept of dynamic reversible modification with implications in fine-tuning the cellular metabolism. In mammals, FTO and ALKBH5 have been initially identified as m(6)A erasers. Recently, FTO m(6)A specificity has been debated as new reports identify FTO targeting N-6,2'-O-dimethyladenosine (m(6)A(m)). The two adenosine demethylases have diverse roles in the metabolism of mRNAs and their activity is involved in key processes, such as embryogenesis, disease or infection. In this article, we review the current knowledge of their function and mechanisms and discuss the existing contradictions in the field. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biochimica et biophysica acta - Gene regulatory mechanisms

  • ISSN

    1874-9399

  • e-ISSN

  • Volume of the periodical

    1862

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    13

  • Pages from-to

    343-355

  • UT code for WoS article

    000462104500013

  • EID of the result in the Scopus database

    2-s2.0-85058499927