The role of RNA adenosine demethylases in the control of gene expression
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F19%3A00109891" target="_blank" >RIV/00216224:14740/19:00109891 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1874939918300439?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1874939918300439?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbagrm.2018.12.001" target="_blank" >10.1016/j.bbagrm.2018.12.001</a>
Alternative languages
Result language
angličtina
Original language name
The role of RNA adenosine demethylases in the control of gene expression
Original language description
RNA modifications are being recognized as an essential factor in gene expression regulation. They play essential roles in germ line development, differentiation and disease. In eukaryotic mRNAs, N-6-adenosine methylation (m(6)A) is the most prevalent internal chemical modification identified to date. The m(6)A pathway involves factors called writers, readers and erasers. m(6)A thus offers an interesting concept of dynamic reversible modification with implications in fine-tuning the cellular metabolism. In mammals, FTO and ALKBH5 have been initially identified as m(6)A erasers. Recently, FTO m(6)A specificity has been debated as new reports identify FTO targeting N-6,2'-O-dimethyladenosine (m(6)A(m)). The two adenosine demethylases have diverse roles in the metabolism of mRNAs and their activity is involved in key processes, such as embryogenesis, disease or infection. In this article, we review the current knowledge of their function and mechanisms and discuss the existing contradictions in the field. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochimica et biophysica acta - Gene regulatory mechanisms
ISSN
1874-9399
e-ISSN
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Volume of the periodical
1862
Issue of the periodical within the volume
3
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
13
Pages from-to
343-355
UT code for WoS article
000462104500013
EID of the result in the Scopus database
2-s2.0-85058499927