Preparation of potential platinum-based metallodrugs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00101566" target="_blank" >RIV/00216224:14740/18:00101566 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Preparation of potential platinum-based metallodrugs
Original language description
Platinum anticancer agents represent one of the great success stories in the field of medicinal inorganic chemistry. However, current chemotherapeutics are rather non-selective and their undesired reactivity during the delivery to cancer tissue is responsible for severe side effects [1]. These anticancer agents would greatly benefit from protection during the transport in blood stream, and targeted delivery towards specific cancer tissues [2]. Therefore, preparation of Pt compounds decorated with anchor-type ligands suitable for encapsulation in macrocyclic cavitands was our goal in this study. Synthesis of novel platinum coordination compounds containing bulky adamantane ligands, their characterization by heteronuclear NMR spectroscopy and binding of these complexes into macrocyclic carriers were discussed. [1] Dilruba, S., Kalayda, G. V., Platinum-based drugs: past, present and future. In Cancer Chemother. Pharmacol., 2016, vol. 77, p. 1103-1124. [2] Wang, X., Guo, Z., Targeting and delivery of platinum-based anticancer drugs. In Chem. Soc. Rev., 2013, vol. 42, p. 202-224.
Czech name
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Czech description
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Project
<a href="/en/project/GA16-05961S" target="_blank" >GA16-05961S: Advanced Carriers for Platinum Drugs</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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