An updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00103871" target="_blank" >RIV/00216224:14740/18:00103871 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.parkreldis.2017.12.030" target="_blank" >http://dx.doi.org/10.1016/j.parkreldis.2017.12.030</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.parkreldis.2017.12.030" target="_blank" >10.1016/j.parkreldis.2017.12.030</a>

Result language

angličtina

Original language name

An updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group

Original language description

This expert working group report proposes an, updated approach to subtype definition of vascular parkinsonism (VaP) based on a review of the existing literature. The persistent lack of consensus on clear terminology and inconsistent conceptual definition of VaP formed the impetus for the current expert recommendation report. The updated diagnostic approach intends to provide a comprehensive tool for clinical practice. The preamble for this initiative is that VaP can be diagnosed in individual patients with possible prognostic and therapeutic consequences and therefore should be recognized as a clinical entity. The diagnosis of VaP is based on the presence of clinical parkinsonism, with variable motor and non motor signs that are corroborated by clinical, anatomic or imaging findings of cerebrovascular disease. Three VaP subtypes are presented: (1) The acute or subacute post-stroke VaP subtype presents with acute or subacute onset of parkinsonism, which is typically asymmetric and responds to dopaminergic drugs; (2) The more frequent insidious onset VaP subtype presents with progressive parkinsonism with prominent postural instability, gait impairment, corticospinal, cerebellar, pseudobulbar, cognitive and urinary symptoms and poor responsiveness to dopaminergic drugs. A higher-level gait disorder occurs frequently as a dominant manifestation in the clinical spectrum of insidious onset VaP, and (3) With the emergence of molecular imaging biomarkers in clinical practice, our diagnostic approach also allows the recognition of mixed or overlapping syndromes of VaP with Parkinson's disease or other neurodegenfor erative parkinsonisms. Directions for future research are also discussed. (C) 2018 Elsevier Ltd. All rights reserved.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PARKINSONISM &amp; RELATED DISORDERS

ISSN

1353-8020

e-ISSN

—

Volume of the periodical

49

Issue of the periodical within the volume

APR

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

9-16

UT code for WoS article

000429395400003

EID of the result in the Scopus database

2-s2.0-85048926311