CD49b defines functionally mature Treg cells that survey skin and vascular tissues
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00106627" target="_blank" >RIV/00216224:14740/18:00106627 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1084/jem.20181442" target="_blank" >http://dx.doi.org/10.1084/jem.20181442</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1084/jem.20181442" target="_blank" >10.1084/jem.20181442</a>
Alternative languages
Result language
angličtina
Original language name
CD49b defines functionally mature Treg cells that survey skin and vascular tissues
Original language description
Regulatory T (Treg) cells prevent autoimmunity by limiting immune responses and inflammation in the secondary lymphoid organs and nonlymphoid tissues. While unique subsets of Treg cells have been described in some nonlymphoid tissues, their relationship to Treg cells in secondary lymphoid organs and circulation remains unclear. Furthermore, it is possible that Treg cells from similar tissue types share largely similar properties. We have identified a short-lived effector Treg cell subset that expresses the alpha(2) integrin, CD49b, and exhibits a unique tissue distribution, being abundant in peripheral blood, vasculature, skin, and skin-draining lymph nodes, but uncommon in the intestines and in viscera-draining lymph nodes. CD49b(+) Treg cells, which display superior functionality revealed by in vitro and in vivo assays, appear to develop after multiple rounds of cell division and TCR-dependent activation. Accordingly, single-cell RNA-seq analysis placed these cells at the apex of the Treg developmental trajectory. These results shed light on the identity and development of a functionally potent subset of mature effector Treg cells that recirculate through and survey peripheral tissues.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Journal of Experimental Medicine
ISSN
0022-1007
e-ISSN
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Volume of the periodical
215
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
19
Pages from-to
2796-2814
UT code for WoS article
000449278300011
EID of the result in the Scopus database
2-s2.0-85056266469