Aire-expressing ILC3-like cells in the lymph node display potent APC features

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00505103" target="_blank" >RIV/68378050:_____/19:00505103 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/19:10403708
Result on the web
<a href="https://rupress.org/jem/article/216/5/1027/121004/Aireexpressing-ILC3like-cells-in-the-lymph-node" target="_blank" >https://rupress.org/jem/article/216/5/1027/121004/Aireexpressing-ILC3like-cells-in-the-lymph-node</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1084/jem.20181430" target="_blank" >10.1084/jem.20181430</a>

Result language
angličtina
Original language name
Aire-expressing ILC3-like cells in the lymph node display potent APC features
Original language description
The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the ´promiscuous´ expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the identity of these cells is poorly understood. Here, we report that Aire protein-expressing cells in lymph nodes exhibit typical group 3 innate lymphoid cell (ILC3) characteristics such as lymphoid morphology, absence of ´classical´ hematopoietic lineage markers, and dependence on ROR gamma t. Aire(+) cells are more frequent among lineage-negative ROR gamma t(+) cells of peripheral lymph nodes as compared with mucosa-draining lymph nodes, display a unique Aire-dependent transcriptional signature, express high surface levels of MHCII and costimulatory molecules, and efficiently present an endogenously expressed model antigen to CD4(+). T cells. These findings define a novel type of ILC3-like cells with potent APC features, suggesting that these cells serve a function in the control of T cell responses.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30102 - Immunology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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