Evaluation of immune repertoire inference methods from RNA-seq data reply

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00106648" target="_blank" >RIV/00216224:14740/18:00106648 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/nbt.4296" target="_blank" >http://dx.doi.org/10.1038/nbt.4296</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/nbt.4296" target="_blank" >10.1038/nbt.4296</a>

Result language
angličtina
Original language name
Evaluation of immune repertoire inference methods from RNA-seq data reply
Original language description
Clinical and biological studies are often aimed at discovering a small fraction of T cell receptor (TCR) or immunoglobulin variants shared between samples or groups of samples—for example, when searching for the common clonotypes involved in response to tumor antigens, infectious agent antigens or self antigens1. In this context, even a single false intersection between immune repertoires extracted from different samples may compromise the utility of the results. Among the scientific community, complementarity-determining region 3 (CDR3) with designated V and J gene segments is the accepted identifier that unambiguously defines TCR alfa- or a beta-chain sequence.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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