Method for identification of condition associated public antigen receptor sequences

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00106651" target="_blank" >RIV/00216224:14740/18:00106651 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.7554/elife.33050" target="_blank" >http://dx.doi.org/10.7554/elife.33050</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7554/elife.33050" target="_blank" >10.7554/elife.33050</a>

Result language
angličtina
Original language name
Method for identification of condition associated public antigen receptor sequences
Original language description
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients, with no need for a control cohort. Our method successfully identifies previously validated Cytomegalovirus and type one diabetes responsive TCR beta sequences
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30102 - Immunology

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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