CXCR3 Identifies Human Naive CD8(+) T Cells with Enhanced Effector Differentiation Potential

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F19%3A00113376" target="_blank" >RIV/00216224:14740/19:00113376 - isvavai.cz</a>
Result on the web
<a href="https://www.jimmunol.org/content/203/12/3179" target="_blank" >https://www.jimmunol.org/content/203/12/3179</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4049/jimmunol.1901072" target="_blank" >10.4049/jimmunol.1901072</a>

Result language
angličtina
Original language name
CXCR3 Identifies Human Naive CD8(+) T Cells with Enhanced Effector Differentiation Potential
Original language description
In mice, the ability of naive T (T-N) cells to mount an effector response correlates with TCR sensitivity for self-derived Ags, which can be quantified indirectly by measuring surface expression levels of CD5. Equivalent findings have not been reported previously in humans. We identified two discrete subsets of human CD8(+) T-N cells, defined by the absence or presence of the chemokine receptor CXCR3. The more abundant CXCR3(+) T-N cell subset displayed an effector-like transcriptional profile and expressed TCRs with physicochemical characteristics indicative of enhanced interactions with peptide-HLA class I Ags. Moreover, CXCR3(+) T-N cells frequently produced IL-2 and TNF in response to nonspecific activation directly ex vivo and differentiated readily into Ag-specific effector cells in vitro. Comparative analyses further revealed that human CXCR3(+) T-N cells were transcriptionally equivalent to murine CXCR3(+) T-N cells, which expressed high levels of CD5. These findings provide support for the notion that effector differentiation is shaped by heterogeneity in the preimmune repertoire of human CD8(+) T cells.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology

Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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