Temporal instability of salience network activity in migraine with aura

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F20%3A00118397" target="_blank" >RIV/00216224:14740/20:00118397 - isvavai.cz</a>

Result on the web

<a href="https://journals.lww.com/pain/Fulltext/2020/04000/Temporal_instability_of_salience_network_activity.20.aspx" target="_blank" >https://journals.lww.com/pain/Fulltext/2020/04000/Temporal_instability_of_salience_network_activity.20.aspx</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/j.pain.0000000000001770" target="_blank" >10.1097/j.pain.0000000000001770</a>

Result language

angličtina

Original language name

Temporal instability of salience network activity in migraine with aura

Original language description

This study aims to investigate whether intranetwork dynamic functional connectivity and causal interactions of the salience network is altered in the interictal term of migraine. Thirty-two healthy controls, 37 migraineurs without aura, and 20 migraineurs with aura were recruited. Participants underwent a T1-weighted scan and resting-state fMRI protocol inside a 1.5T MR scanner. We obtained average spatial maps of resting-state networks using group independent component analysis, which yielded subject-specific time series through a dual regression approach. Salience network regions of interest (bilateral insulae and prefrontal cortices, dorsal anterior cingulate cortex) were obtained from the group average map through cluster-based thresholding. To describe intranetwork connectivity, average and dynamic conditional correlation was calculated. Causal interactions between the default-mode, dorsal attention, and salience network were characterised by spectral Granger's causality. Time-averaged correlation was lower between the right insula and prefrontal cortex in migraine without aura vs with aura and healthy controls (P &lt; 0.038, P &lt; 0.037). Variance of dynamic conditional correlation was higher in migraine with aura vs healthy controls and migraine with aura vs without aura between the right insula and dorsal anterior cingulate cortex (P &lt; 0.011, P &lt; 0.026), and in migraine with aura vs healthy controls between the dorsal anterior cingulate and left prefrontal cortex (P &lt; 0.021). Causality was weaker in the &lt;0.05 Hz frequency range between the salience and dorsal attention networks in migraine with aura (P &lt; 0.032). Overall, migraineurs with aura exhibit more fluctuating connections in the salience network, which also affect network interactions, and could be connected to altered cortical excitability and increased sensory gain.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pain : the journal of the international association for the study of pain.

ISSN

0304-3959

e-ISSN

—

Volume of the periodical

161

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

856-864

UT code for WoS article

000524199500020

EID of the result in the Scopus database

2-s2.0-85082145767