Two subsets of stem-like CD8(+)memory T cell progenitors with distinct fate commitments in humans
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F20%3A00118398" target="_blank" >RIV/00216224:14740/20:00118398 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41590-020-0791-5" target="_blank" >https://www.nature.com/articles/s41590-020-0791-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41590-020-0791-5" target="_blank" >10.1038/s41590-020-0791-5</a>
Alternative languages
Result language
angličtina
Original language name
Two subsets of stem-like CD8(+)memory T cell progenitors with distinct fate commitments in humans
Original language description
The identity of stem-cell memory progenitor cells has been unclear. Lugli and colleagues use high-dimensional approaches to identify two new progenitor populations of human T cells-one giving rise to a functional lineage, the other to an exhausted-like one. T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained unclear, precluding a full understanding of the differentiation trajectories that underpin the heterogeneity of antigen-experienced T cells. We used a systematic approach guided by single-cell RNA-sequencing data to map the organizational structure of the human CD8(+)memory T cell pool under physiological conditions. We identified two previously unrecognized subsets of clonally, epigenetically, functionally, phenotypically and transcriptionally distinct stem-like CD8(+)memory T cells. Progenitors lacking the inhibitory receptors programmed death-1 (PD-1) and T cell immunoreceptor with Ig and ITIM domains (TIGIT) were committed to a functional lineage, whereas progenitors expressing PD-1 and TIGIT were committed to a dysfunctional, exhausted-like lineage. Collectively, these data reveal the existence of parallel differentiation programs in the human CD8(+)memory T cell pool, with potentially broad implications for the development of immunotherapies and vaccines.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature immunology
ISSN
1529-2908
e-ISSN
—
Volume of the periodical
21
Issue of the periodical within the volume
12
Country of publishing house
DE - GERMANY
Number of pages
14
Pages from-to
„1552“-„+“
UT code for WoS article
000577043300002
EID of the result in the Scopus database
2-s2.0-85092340566