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Two subsets of stem-like CD8(+)memory T cell progenitors with distinct fate commitments in humans

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F20%3A00118398" target="_blank" >RIV/00216224:14740/20:00118398 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.nature.com/articles/s41590-020-0791-5" target="_blank" >https://www.nature.com/articles/s41590-020-0791-5</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/s41590-020-0791-5" target="_blank" >10.1038/s41590-020-0791-5</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Two subsets of stem-like CD8(+)memory T cell progenitors with distinct fate commitments in humans

  • Original language description

    The identity of stem-cell memory progenitor cells has been unclear. Lugli and colleagues use high-dimensional approaches to identify two new progenitor populations of human T cells-one giving rise to a functional lineage, the other to an exhausted-like one. T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained unclear, precluding a full understanding of the differentiation trajectories that underpin the heterogeneity of antigen-experienced T cells. We used a systematic approach guided by single-cell RNA-sequencing data to map the organizational structure of the human CD8(+)memory T cell pool under physiological conditions. We identified two previously unrecognized subsets of clonally, epigenetically, functionally, phenotypically and transcriptionally distinct stem-like CD8(+)memory T cells. Progenitors lacking the inhibitory receptors programmed death-1 (PD-1) and T cell immunoreceptor with Ig and ITIM domains (TIGIT) were committed to a functional lineage, whereas progenitors expressing PD-1 and TIGIT were committed to a dysfunctional, exhausted-like lineage. Collectively, these data reveal the existence of parallel differentiation programs in the human CD8(+)memory T cell pool, with potentially broad implications for the development of immunotherapies and vaccines.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30102 - Immunology

Result continuities

  • Project

    <a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nature immunology

  • ISSN

    1529-2908

  • e-ISSN

  • Volume of the periodical

    21

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    14

  • Pages from-to

    „1552“-„+“

  • UT code for WoS article

    000577043300002

  • EID of the result in the Scopus database

    2-s2.0-85092340566