Bystander activation in memory and antigen- inexperienced memory-like CD8 T cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00570976" target="_blank" >RIV/68378050:_____/23:00570976 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10471653
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0952791523000183?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0952791523000183?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.coi.2023.102299" target="_blank" >10.1016/j.coi.2023.102299</a>
Alternative languages
Result language
angličtina
Original language name
Bystander activation in memory and antigen- inexperienced memory-like CD8 T cells
Original language description
Antigen-induced memory T cells undergo counterintuitive activation in an antigen-independent manner, which is called bystander response. Although it is well documented that memory CD8+ T cells produce IFN gamma and upregulate the cytotoxic program upon the stimulation with inflammatory cytokines, there is only rare evidence that this provides an actual protection against pathogens in immunocompetent individuals. One of the reasons might be numerous antigen-inexperienced memory-like T cells that are also capable of the bystander response. Little is known about the bystander protection of memory and memory-like T cells and their redundancies with innate-like lymphocytes in humans because of the interspecies differences and the lack of controlled experiments. However, it has been proposed that IL-15/ NKG2D-driven bystander activation of memory T cells drives protection or immunopathology in particular human diseases.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30102 - Immunology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Opinion in Immunology
ISSN
0952-7915
e-ISSN
1879-0372
Volume of the periodical
82
Issue of the periodical within the volume
JUN
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
102299
UT code for WoS article
000955180400001
EID of the result in the Scopus database
2-s2.0-85150828447