Capsid opening enables genome release of iflaviruses.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F21%3A00118990" target="_blank" >RIV/00216224:14740/21:00118990 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/21:43919052
Result on the web
<a href="https://www.science.org/doi/pdf/10.1126/sciadv.abd7130" target="_blank" >https://www.science.org/doi/pdf/10.1126/sciadv.abd7130</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/sciadv.abd7130" target="_blank" >10.1126/sciadv.abd7130</a>
Alternative languages
Result language
angličtina
Original language name
Capsid opening enables genome release of iflaviruses.
Original language description
The family Iflaviridae includes economically important viruses of the western honeybee such as deformed wing virus, slow bee paralysis virus, and sacbrood virus. Iflaviruses have nonenveloped virions and capsids organized with icosahedral symmetry. The genome release of iflaviruses can be induced in vitro by exposure to acidic pH, implying that they enter cells by endocytosis. Genome release intermediates of iflaviruses have not been structurally characterized. Here, we show that conformational changes and expansion of iflavirus RNA genomes, which are induced by acidic pH, trigger the opening of iflavirus particles. Capsids of slow bee paralysis virus and sacbrood virus crack into pieces. In contrast, capsids of deformed wing virus are more flexible and open like flowers to release their genomes. The large openings in iflavirus particles enable the fast exit of genomes from capsids, which decreases the probability of genome degradation by the RNases present in endosomes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science advances
ISSN
2375-2548
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1-9
UT code for WoS article
000605159200031
EID of the result in the Scopus database
2-s2.0-85098733076