The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F21%3A00124232" target="_blank" >RIV/00216224:14740/21:00124232 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/22/16/8527" target="_blank" >https://www.mdpi.com/1422-0067/22/16/8527</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms22168527" target="_blank" >10.3390/ijms22168527</a>

Result language
angličtina
Original language name
The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers
Original language description
MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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