Isoform-Directed Control of c-Myc Functions: Understanding the Balance from Proliferation to Growth Arrest

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F23%3A10158270" target="_blank" >RIV/00098892:_____/23:10158270 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/23:73621920 RIV/61989592:15640/23:73621920

Result on the web

<a href="https://www.mdpi.com/1422-0067/24/24/17524" target="_blank" >https://www.mdpi.com/1422-0067/24/24/17524</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms242417524" target="_blank" >10.3390/ijms242417524</a>

Result language

angličtina

Original language name

Isoform-Directed Control of c-Myc Functions: Understanding the Balance from Proliferation to Growth Arrest

Original language description

The transcription factor c-Myc, a key regulator of cellular processes, has long been associated with roles in cell proliferation and apoptosis. This review analyses the multiple functions of c-Myc by examining the different c-Myc isoforms in detail. The impact of different c-Myc isoforms, in particular p64 and p67, on fundamental biological processes remains controversial. It is necessary to investigate the different isoforms in the context of proto-oncogenesis. The current knowledge base suggests that neoplastic lesions may possess the means for self-destruction via increased c-Myc activity. This review presents the most relevant information on the c-Myc locus and focuses on a number of isoforms, including p64 and p67. This compilation provides a basis for the development of therapeutic approaches that target the potent growth arresting and pro-apoptotic functions of c-Myc. This information can then be used to develop targeted interventions against specific isoforms with the aim of shifting the oncogenic effects of c-Myc from pro-proliferative to pro-apoptotic. The research summarised in this review can deepen our understanding of how c-Myc activity contributes to different cellular responses, which will be crucial in developing effective therapeutic strategies; for example, isoform-specific approaches may allow for precise modulation of c-Myc function.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30107 - Medicinal chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1661-6596

e-ISSN

1422-0067

Volume of the periodical

24

Issue of the periodical within the volume

24

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

17524

UT code for WoS article

001131454800001

EID of the result in the Scopus database

2-s2.0-85180669104