THE CELL SURVIVAL FUNCTION OF JNK

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18450%2F14%3A50002642" target="_blank" >RIV/62690094:18450/14:50002642 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

THE CELL SURVIVAL FUNCTION OF JNK

Original language description

c-Jun N-terminal kinases (JNK) can be activated by multiple environmental stress, leading to varied and contradictory cellular response. JNK mediates cell apoptosis as well as cell survival and proliferation. JNK1 and JNK2 as the major members are able to perform similar and distinct biological functions. This review mainly discussed the mechanism of JNK cell survival function and the distinct roles of JNK1 and JNK2 in cell apoptosis and proliferation. Transient JNK activation may be important for mediating a survival response in TNF-treated cells and chronic JNK activation may contribute to apoptotic response. Other signal transduction pathways may also articipate in its protective function. Abrogation of p38 MAPK pathway is assumed to induce pro-survival role. JNK suppresses apoptosis via phosphorylation of the pro-apoptotic Bcl-2 family protein BAD. Activated JNK inactivates suppressors of the apoptotic machinery, thereby ?breaking the brake? on apoptosis.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

KA - Militarism

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Vojenské zdravotnické listy=Military medical science letters

ISSN

0372-7025

e-ISSN

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Volume of the periodical

83

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

28-33

UT code for WoS article

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EID of the result in the Scopus database

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