Single-cell RNA-sequencing enables tracking and characterization of rare CLL cells with the potential to cause refractoriness.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F23%3A00131049" target="_blank" >RIV/00216224:14740/23:00131049 - isvavai.cz</a>
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10429134/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10429134/</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Single-cell RNA-sequencing enables tracking and characterization of rare CLL cells with the potential to cause refractoriness.
Original language description
Chronic lymphocytic leukemia (CLL) is considered an incurable disease due to the limited ability of current treatment options to completely eradicate leukemic cells. The therapy selection pressure favors the preferential proliferation of rare resistant cells, leading to recurrent relapses. Early detection of these rare cells holds the potential to assist in selecting appropriate therapy. To explore the possibility to identify and characterize rare populations of CLL cells resistant to treatment and causing relapses, and trace the presence of such cells during the disease course by single-cell RNA sequencing (scRNA-seq).
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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