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Cycles of satellite and transposon evolution in <i>Arabidopsis</i> centromeres

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F23%3A00134414" target="_blank" >RIV/00216224:14740/23:00134414 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.nature.com/articles/s41586-023-06062-z#citeas" target="_blank" >https://www.nature.com/articles/s41586-023-06062-z#citeas</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/s41586-023-06062-z" target="_blank" >10.1038/s41586-023-06062-z</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cycles of satellite and transposon evolution in <i>Arabidopsis</i> centromeres

  • Original language description

    Centromeres are critical for cell division, loading CENH3 or CENPA histone variant nucleosomes, directing kinetochore formation and allowing chromosome segregation(1,2). Despite their conserved function, centromere size and structure are diverse across species. To understand this centromere paradox(3,4), it is necessary to know how centromeric diversity is generated and whether it reflects ancient trans-species variation or, instead, rapid post-speciation divergence. To address these questions, we assembled 346 centromeres from 66 Arabidopsis thaliana and 2 Arabidopsis lyrata accessions, which exhibited a remarkable degree of intra- and inter-species diversity. A. thaliana centromere repeat arrays are embedded in linkage blocks, despite ongoing internal satellite turnover, consistent with roles for unidirectional gene conversion or unequal crossover between sister chromatids in sequence diversification. Additionally, centrophilic ATHILA transposons have recently invaded the satellite arrays. To counter ATHILA invasion, chromosome-specific bursts of satellite homogenization generate higher-order repeats and purge transposons, in line with cycles of repeat evolution. Centromeric sequence changes are even more extreme in comparison between A. thaliana and A. lyrata. Together, our findings identify rapid cycles of transposon invasion and purging through satellite homogenization, which drive centromere evolution and ultimately contribute to speciation.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10611 - Plant sciences, botany

Result continuities

  • Project

    <a href="/en/project/GA21-03909S" target="_blank" >GA21-03909S: Unlocking evolutionary secrets of false flax and its relatives</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nature

  • ISSN

    0028-0836

  • e-ISSN

    1476-4687

  • Volume of the periodical

    618

  • Issue of the periodical within the volume

    7965

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    34

  • Pages from-to

    1-34

  • UT code for WoS article

    000991386800003

  • EID of the result in the Scopus database

    2-s2.0-85159477946