Cycles of satellite and transposon evolution in <i>Arabidopsis</i> centromeres
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F23%3A00134414" target="_blank" >RIV/00216224:14740/23:00134414 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41586-023-06062-z#citeas" target="_blank" >https://www.nature.com/articles/s41586-023-06062-z#citeas</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41586-023-06062-z" target="_blank" >10.1038/s41586-023-06062-z</a>
Alternative languages
Result language
angličtina
Original language name
Cycles of satellite and transposon evolution in <i>Arabidopsis</i> centromeres
Original language description
Centromeres are critical for cell division, loading CENH3 or CENPA histone variant nucleosomes, directing kinetochore formation and allowing chromosome segregation(1,2). Despite their conserved function, centromere size and structure are diverse across species. To understand this centromere paradox(3,4), it is necessary to know how centromeric diversity is generated and whether it reflects ancient trans-species variation or, instead, rapid post-speciation divergence. To address these questions, we assembled 346 centromeres from 66 Arabidopsis thaliana and 2 Arabidopsis lyrata accessions, which exhibited a remarkable degree of intra- and inter-species diversity. A. thaliana centromere repeat arrays are embedded in linkage blocks, despite ongoing internal satellite turnover, consistent with roles for unidirectional gene conversion or unequal crossover between sister chromatids in sequence diversification. Additionally, centrophilic ATHILA transposons have recently invaded the satellite arrays. To counter ATHILA invasion, chromosome-specific bursts of satellite homogenization generate higher-order repeats and purge transposons, in line with cycles of repeat evolution. Centromeric sequence changes are even more extreme in comparison between A. thaliana and A. lyrata. Together, our findings identify rapid cycles of transposon invasion and purging through satellite homogenization, which drive centromere evolution and ultimately contribute to speciation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany
Result continuities
Project
<a href="/en/project/GA21-03909S" target="_blank" >GA21-03909S: Unlocking evolutionary secrets of false flax and its relatives</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature
ISSN
0028-0836
e-ISSN
1476-4687
Volume of the periodical
618
Issue of the periodical within the volume
7965
Country of publishing house
DE - GERMANY
Number of pages
34
Pages from-to
1-34
UT code for WoS article
000991386800003
EID of the result in the Scopus database
2-s2.0-85159477946