Nanoparticle induced fusion of lipid membranes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F24%3A00136132" target="_blank" >RIV/00216224:14740/24:00136132 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2024/nr/d4nr00591k" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2024/nr/d4nr00591k</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d4nr00591k" target="_blank" >10.1039/d4nr00591k</a>
Alternative languages
Result language
angličtina
Original language name
Nanoparticle induced fusion of lipid membranes
Original language description
Membrane fusion is crucial for infection of enveloped viruses, cellular transport, and drug delivery via liposomes. Nanoparticles can serve as fusogenic agents facilitating such membrane fusion for direct transmembrane transport. However, the underlying mechanisms of nanoparticle-induced fusion and the ideal properties of such nanoparticles remain largely unknown. Here, we used molecular dynamics simulations to investigate the efficacy of spheroidal nanoparticles with different size, prolateness, and ligand interaction strengths to enhance fusion between vesicles. By systematically varying nanoparticle properties, we identified how each parameter affects the fusion process and determined the optimal parameter range that promotes fusion. These findings provide valuable insights for the design and optimization of fusogenic nanoparticles with potential biotechnological and biomedical applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21000 - Nano-technology
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanoscale
ISSN
2040-3364
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
21
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
10221-10229
UT code for WoS article
001209187800001
EID of the result in the Scopus database
2-s2.0-85191833178