Designing spheroidal nanoparticles to induce membrane fusion of liposomes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F23%3A00132214" target="_blank" >RIV/00216224:14740/23:00132214 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Designing spheroidal nanoparticles to induce membrane fusion of liposomes
Original language description
The efficient delivery of drugs into cells remains a great challenge. Liposome drug delivery often relies on endocytosis to enter the cell, which usually leads to lysosomal degradation, reducing their delivery efficacy. Recently, a novel delivery approach has emerged, utilizing nanoparticle-induced fusion between liposomes and cells, thus avoiding the endocytic pathway. However, the underlying mechanisms of nanoparticle-induced fusion and the ideal properties of such nanoparticles remain largely unknown. We used molecular dynamics simulations to investigate the efficacy of spheroid nanoparticles with different size, prolateness, and ligand interaction strengths in enhancing fusion between vesicles. By systematically varying nanoparticle properties, we identified how each parameter affects the fusion process and the optimal parameter range that promotes fusion. These findings provide valuable insights for the design and optimization of fusogenic nanoparticles with potential biotechnological and biomedical applications.
Czech name
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Czech description
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Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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