Translation control and co-translational processes in health and disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F24%3A00137991" target="_blank" >RIV/00216224:14740/24:00137991 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/23:00132412
Result on the web
<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/48/87" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/48/87</a>
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Translation control and co-translational processes in health and disease
Original language description
Co-translational quality control is triggered as aresponse to translational stalling events. Yet, different molecular mechanisms are employed for the recognition of these stalls and to trigger downstream rescue and quality control pathways. While the recognition of individual stalled ribosomes is poorly understood, the use of collided ribosomes as a proxy for the recognition of translation problems in the cell is conserved from bacteria to humans1–3. In eukaryotes, co-translational quality-control processes triggered by ribosome collisions accomplish several tasks and eventually trigger stress response signalling pathways. grated stress response (ISR) is a highly conserved eukaryotic mechanism for integrating multiple signals to reprogram gene expression. These signals are conveyed by protein kinases that phosphorylate the α subunit of the initiation factor 2 (eIF2). Mammals have four known eIF2α kinases: GCN2, PERK, HRI, and PKR, which are activated in response to amino-acid starvation, ER stress, cytoplasmic protein misfolding and viral infection, respectively.
Czech name
—
Czech description
—

Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)