A Whole-Brain Model of the Aging Brain During Slow Wave Sleep
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F24%3A00138902" target="_blank" >RIV/00216224:14740/24:00138902 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1523/ENEURO.0180-24.2024" target="_blank" >https://doi.org/10.1523/ENEURO.0180-24.2024</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1523/ENEURO.0180-24.2024" target="_blank" >10.1523/ENEURO.0180-24.2024</a>
Alternative languages
Result language
angličtina
Original language name
A Whole-Brain Model of the Aging Brain During Slow Wave Sleep
Original language description
Age-related brain changes affect sleep and are reflected in properties of sleep slow-waves, however, the precise mechanisms behind these changes are still not completely understood. Here, we adapt a previously established whole-brain model relating structural connectivity changes to resting state dynamics, and extend it to a slow-wave sleep brain state. In particular, starting from a representative connectome at the beginning of the aging trajectory, we have gradually reduced the inter-hemispheric connections, and simulated sleep-like slow-wave activity. We show that the main empirically observed trends, namely a decrease in duration and increase in variability of the slow waves are captured by the model. Furthermore, comparing the simulated EEG activity to the source signals, we suggest that the empirically observed decrease in amplitude of the slow waves is caused by the decrease in synchrony between brain regions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ENEURO
ISSN
2373-2822
e-ISSN
2373-2822
Volume of the periodical
11
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
1-12
UT code for WoS article
001350900800001
EID of the result in the Scopus database
2-s2.0-85208772154