Synthesis, Structural Study, In vitro Antitumour and Trypanocidal Activity of Tetrakis(3-methoxypropyl)tin and (3-Methoxypropyl)tin Chlorides

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F03%3A00000548" target="_blank" >RIV/00216275:25310/03:00000548 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Synthesis, Structural Study, In vitro Antitumour and Trypanocidal Activity of Tetrakis(3-methoxypropyl)tin and (3-Methoxypropyl)tin Chlorides

Original language description

The set of four water-soluble (3-methoxypropyl)stannanes with the general formula (CH3OCH2CH2CH2)xSnCl4-x where x = 4 (1), x = 3 (2), x = 2 (3) and x = 1 (4), was prepared. For 3 and 4, which were isolated in crystalline state, it was shown by X ray diffraction that the tin atom is coordinated in distorted octahedral and trigonal-bipyramidal geometry, respectively, i.e. in both cases, the oxygen atoms of 3-methoxypropyl groups were coordinated to the central tin atom forming chelates. For all compounds,structures in CDCl3 and DMSO-d6 solutions were proposed from 13C and 119Sn NMR spectra. In CDCl3 solutions, the degree of donor-acceptor bonding between the central tin atom and oxygen atom of 3 methoxypropyl substituent was evaluated on the basis of 17O NMR chemical shifts and 3,6J(1H,119Sn) long-range coupling constants. Compounds 2 and 3 exhibited promising in vitro antitumour and trypanocidal activity.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CA - Inorganic chemistry

OECD FORD branch

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Project

<a href="/en/project/LN00A028" target="_blank" >LN00A028: New inorganic compounds and advanced materials</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Inorganic Chemistry

ISSN

1434-1948

e-ISSN

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Volume of the periodical

2003

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

143-148

UT code for WoS article

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EID of the result in the Scopus database

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