Synthesis, structural study, and in vitro trypanocidal and antitumour activities of tetrakis(3-methoxypropyl)tin and (3-methoxypropyl)tin chlorides.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F03%3A55033007" target="_blank" >RIV/61389013:_____/03:55033007 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Synthesis, structural study, and in vitro trypanocidal and antitumour activities of tetrakis(3-methoxypropyl)tin and (3-methoxypropyl)tin chlorides.

Original language description

A set of four water-soluble (3-methoxypropyl)stannanes of general formula (CH3OCH2CH2CH2)(x)SnCl4-x, where x = 4 (1), x = 3 (2), x = 2 (3), and x = 1 (4), was prepared. For 3 and 4, which were isolated in the crystalline state, it was shown by X-ray diffraction that the tin atom is coordinated in distorted octahedral and trigonal-bipyramidal geometries, respectively (i.e., the oxygen atoms of the 3-methoxypropyl groups were coordinated to the central tin atom in both cases, forming chelates). For all compounds, structures in CDCl3 and [D-6]DMSO solutions were proposed on the basis of their C-13 and Sn-119 NMR spectra. In CDCl3 solution, the degree of donor-acceptor bonding between the central tin atom and oxygen atom of the 3-methoxypropyl substituentwas evaluated on the basis of O-17 NMR chemical shifts and 3,6J(H-1,Sn-119) long-range coupling constants. Compounds 2 and 3 exhibited promising antitumour and trypanocidal activities in vitro.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BM - Solid-state physics and magnetism

OECD FORD branch

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Project

<a href="/en/project/LN00A028" target="_blank" >LN00A028: New inorganic compounds and advanced materials</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Inorganic Chemistry

ISSN

1434-1948

e-ISSN

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Volume of the periodical

1

Issue of the periodical within the volume

N/A

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

143-148

UT code for WoS article

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EID of the result in the Scopus database

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