EXPERIMENTAL AND THEORETICAL STUDY OF THE FIRST VANADOCENE(IV) COMPLEXES OF a-AMINO ACID PREPARED FROM THE ANTITUMOR AGENT VANADOCENE DICHLORIDE
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F06%3A00004296" target="_blank" >RIV/00216275:25310/06:00004296 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
EXPERIMENTAL AND THEORETICAL STUDY OF THE FIRST VANADOCENE(IV) COMPLEXES OF a-AMINO ACID PREPARED FROM THE ANTITUMOR AGENT VANADOCENE DICHLORIDE
Original language description
The first bioinorganic vanadocene(IV) complexes of a-amino acid ([Cp2Vaa]Cl; aa = glycine, L-alanine, L-valine) were prepared by reaction of antitumor active vanadocene dichloride [Cp2VCl2] (Cp = h5-C5H5) (1) and a-amino acids in aqueous methanol. Analogous PF6- ionic complexes were obtained by methathetical reactions of chloride complexes with KPF6. These compounds are of great interest as the model systems for the vanadocene moiety-binding to proteins. All complexes have been characterized by elemental analyses, IR and Raman spectroscopy and especially by EPR spectroscopy. On the basis of EPR spectra was suggested the chelate bound in all the studied complexes that is realize via the carboxylato and amino groups. This structure was also confirmed byDFT calculations.
Czech name
EXPERIMENTAL AND THEORETICAL STUDY OF THE FIRST VANADOCENE(IV) COMPLEXES OF a-AMINO ACID PREPARED FROM THE ANTITUMOR AGENT VANADOCENE DICHLORIDE
Czech description
The first bioinorganic vanadocene(IV) complexes of a-amino acid ([Cp2Vaa]Cl; aa = glycine, L-alanine, L-valine) were prepared by reaction of antitumor active vanadocene dichloride [Cp2VCl2] (Cp = h5-C5H5) (1) and a-amino acids in aqueous methanol. Analogous PF6- ionic complexes were obtained by methathetical reactions of chloride complexes with KPF6. These compounds are of great interest as the model systems for the vanadocene moiety-binding to proteins. All complexes have been characterized by elemental analyses, IR and Raman spectroscopy and especially by EPR spectroscopy. On the basis of EPR spectra was suggested the chelate bound in all the studied complexes that is realize via the carboxylato and amino groups. This structure was also confirmed byDFT calculations.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA203%2F03%2F1071" target="_blank" >GA203/03/1071: Structural analysis of organometallic compounds using mass spectrometry with MSn analysis</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Inorganic Chemistry
ISSN
0020-1669
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
2156-2162
UT code for WoS article
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EID of the result in the Scopus database
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