The Interaction of Antitumor Active Vanadocene Dichloride with Sulphur Containing Amino Acids

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F07%3A00006311" target="_blank" >RIV/00216275:25310/07:00006311 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The Interaction of Antitumor Active Vanadocene Dichloride with Sulphur Containing Amino Acids

Original language description

Vanadocene dichloride (1) reacts with sulphur-containing amino acids, cysteine and methionine, giving new complexes with five- or six-membered chelate ring, but the structure of isolated compounds is affected by the pH value of the reaction mixture. Methionine reacts with aqueous 1 in the pH range of 3 - 8 affording chelate structure [Cp2V(N,O-met)]Cl (4). Similar reaction with cysteine gives two different products depending on pH. In the acidic solution, the complex [Cp2V(O,S-cys)]Cl (2) is present, but in neutral media the compound [Cp2V(N,S-cys)] (3) could be identified. On inspection of spectroscopic measurements, particularly EPR and vibrational spectroscopy, it is evident that sulphur atom of amino acid is bonded directly to the vanadium atom of[Cp2V]2+ moiety. For the purpose of comparison the complexes [Cp2V(O,S-mpa)] (5) and [Cp2V(N,S-csam)]+ (6a) with related chelating ligands, 3-mercaptopropionic acid (mpa) and cysteamine (csam), respectively, were prepared and spectroscopi

Czech name

Interakce vanadocendichloridu s aminokyselinami obsahující síru

Czech description

Vanadocene dichloride (1) reacts with sulphur-containing amino acids, cysteine and methionine, giving new complexes with five- or six-membered chelate ring, but the structure of isolated compounds is affected by the pH value of the reaction mixture. Methionine reacts with aqueous 1 in the pH range of 3 - 8 affording chelate structure [Cp2V(N,O-met)]Cl (4). Similar reaction with cysteine gives two different products depending on pH. In the acidic solution, the complex [Cp2V(O,S-cys)]Cl (2) is present, but in neutral media the compound [Cp2V(N,S-cys)] (3) could be identified. On inspection of spectroscopic measurements, particularly EPR and vibrational spectroscopy, it is evident that sulphur atom of amino acid is bonded directly to the vanadium atom of[Cp2V]2+ moiety. For the purpose of comparison the complexes [Cp2V(O,S-mpa)] (5) and [Cp2V(N,S-csam)]+ (6a) with related chelating ligands, 3-mercaptopropionic acid (mpa) and cysteamine (csam), respectively, were prepared and spectroscopi

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CA - Inorganic chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Oranometallic Chemistry

ISSN

0022-328X

e-ISSN

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Volume of the periodical

692

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

3758-3764

UT code for WoS article

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EID of the result in the Scopus database

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