1,1-Dimethylvanadocene -amino acid complexes: synthesis, characterization and antimicrobial behavior toward Escherichia coli B

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F06%3A00004373" target="_blank" >RIV/00216275:25310/06:00004373 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

1,1-Dimethylvanadocene -amino acid complexes: synthesis, characterization and antimicrobial behavior toward Escherichia coli B

Original language description

Eight water-soluble 1,1-dimethylvanadocene amino acid complexes have been prepared via the reaction of (MeCp)2VCl2 (2) with one equivalent of amino acid (aa) in water affording [(MeCp)2V(aa)]Cl, where aa is glycine (3), L-alanine (4), L-valine (5), L-leucine (6), L-isoleucine (7), L-phenylalanine (8), L-histidine (9) and L-tryptophane (10). All prepared complexes have been characterized by EPR, IR and Raman spectroscopy, elemental analysis and mass spectrometry. Molecular structures of [(MeCp)2V(ala)]BPh4*CH3OH (11), [(MeCp)2V(leu)]PF6 (12) and [(MeCp)2V(ile)]PF6 (13) were determined by X-ray diffraction analysis. Cytotoxic properties of complexes 2-10 were investigated toward Escherichia coli B and compared with analogical unsubstituted vanadocene compounds (1, 14-21). The results showed that 1,1-dimethylvanadocene amino acid complexes have identical or slightly higher antiproliferative activity then their unsubstituted analogs.

Czech name

1,1-Dimethylvanadocene -amino acid complexes: synthesis, characterization and antimicrobial behavior toward Escherichia coli B

Czech description

Eight water-soluble 1,1-dimethylvanadocene amino acid complexes have been prepared via the reaction of (MeCp)2VCl2 (2) with one equivalent of amino acid (aa) in water affording [(MeCp)2V(aa)]Cl, where aa is glycine (3), L-alanine (4), L-valine (5), L-leucine (6), L-isoleucine (7), L-phenylalanine (8), L-histidine (9) and L-tryptophane (10). All prepared complexes have been characterized by EPR, IR and Raman spectroscopy, elemental analysis and mass spectrometry. Molecular structures of [(MeCp)2V(ala)]BPh4*CH3OH (11), [(MeCp)2V(leu)]PF6 (12) and [(MeCp)2V(ile)]PF6 (13) were determined by X-ray diffraction analysis. Cytotoxic properties of complexes 2-10 were investigated toward Escherichia coli B and compared with analogical unsubstituted vanadocene compounds (1, 14-21). The results showed that 1,1-dimethylvanadocene amino acid complexes have identical or slightly higher antiproliferative activity then their unsubstituted analogs.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CA - Inorganic chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Applied Organometallic Chemistry

ISSN

0268-2605

e-ISSN

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Volume of the periodical

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Issue of the periodical within the volume

20

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

603-609

UT code for WoS article

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EID of the result in the Scopus database

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