New chiral synthons of 13C- or 15N-labeled ?-aminoacids.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F07%3A00006066" target="_blank" >RIV/00216275:25310/07:00006066 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
New chiral synthons of 13C- or 15N-labeled ?-aminoacids.
Original language description
For the synthesis of a structure carrying a label in any of the above-mentioned positions, the corresponding labelled glycine synthon could be prepared from commercially available mono-, di- or tri-labelled glycine. This synthon is further monoalkylatedwith a suitable electrophile in order to introduce a (protected) side chain, followed by methylation by labelled or non-labelled methyl iodide. An optimization was done in order to increase yields of the complexes and decrease consumption of expensive labelled glycine. Similar optimization of synthesis of a precursor for a-(13C)methyltyrosine gave the ratio of BPB:amino acid:nickel nitrate 1:1.4:1.5. This ratio allows to achieve 87% yield of the complex. The development of more diastereoselective synthons is underway.
Czech name
New chiral synthons of 13C- or 15N-labeled ?-aminoacids.
Czech description
For the synthesis of a structure carrying a label in any of the above-mentioned positions, the corresponding labelled glycine synthon could be prepared from commercially available mono-, di- or tri-labelled glycine. This synthon is further monoalkylatedwith a suitable electrophile in order to introduce a (protected) side chain, followed by methylation by labelled or non-labelled methyl iodide. An optimization was done in order to increase yields of the complexes and decrease consumption of expensive labelled glycine. Similar optimization of synthesis of a precursor for a-(13C)methyltyrosine gave the ratio of BPB:amino acid:nickel nitrate 1:1.4:1.5. This ratio allows to achieve 87% yield of the complex. The development of more diastereoselective synthons is underway.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Labelled Compounds and Radiopharmaceuticals
ISSN
0362-4803
e-ISSN
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Volume of the periodical
50
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
2
Pages from-to
554-555
UT code for WoS article
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EID of the result in the Scopus database
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