Development of metallcomplex amino acids synthons for the asymmetric preparation of alpha-amino acids by stereoselective introduction of a side chain

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F10%3A63510063" target="_blank" >RIV/70883521:28110/10:63510063 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Development of metallcomplex amino acids synthons for the asymmetric preparation of alpha-amino acids by stereoselective introduction of a side chain
Original language description
In this communication the evaluation of eleven new metalocomplex alanine synthons bearing C2-symmetric benzyl groups with electron-donating and electron-withdrawing substituents is described. Alpha-Methylated glycine synthons (alanine complexes) were evaluated alongside alanine synthons in order to obtain a deeper understanding of the relationship between their structures and stereochemistry of monoalkylated products and to choose several candidates for their further tests for stereospecific preparationof 6-[18F]FDOPA. Glycine-derived analogues of the complexes 3-5 are the best candidates for the development of a 6-[18F]FDOPA preparation procedure. In the model epimerization reaction they demonstrated the best performance, much better compared to thepreviously described compound 2. Complexes 3, 5, and 8 are the best in asymmetric preparation of beta-13C monolabelled alpha-aminoisobutyric acid. The have to be tested in the preparation of alpha-methyl amino acids like 6-[18F]-alpha-met
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)