Development of metallocomplex amino acids synthons for the asymmetric preparation of alfa-amino acids by stereoselective introduction of a side chain. Evaluation of the model asymmetric preparation of alanine and beta-C-13 monolabelled alfa-aminoisobutyric acid

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F10%3A39881300" target="_blank" >RIV/00216275:25310/10:39881300 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Development of metallocomplex amino acids synthons for the asymmetric preparation of alfa-amino acids by stereoselective introduction of a side chain. Evaluation of the model asymmetric preparation of alanine and beta-C-13 monolabelled alfa-aminoisobutyric acid
Original language description
The evaluation of 11 new metallocomplex alanine synthons bearing C-2-symmetric benzyl groups with electron-donating and withdrawing substituents is described. alpha-Methylated glycine synthons (alanine complexes) were evaluated alongside alanine synthonsin order to obtain a deeper understanding of the relationship between their structures and stereochemistry of monoalkylated products and to choose several candidates for their further tests for stereospecific preparation of 6-[F-18]FDOPA. Glycine-derived analogues of the complexes 3-5 are the best candidates for the development of a 6-[F-18]FDOPA preparation procedure. In the model epimerisation reaction they demonstrated the best performance, much better compared to the previously described compound 2. Complexes 3, 5 and 8 are the best in asymmetric preparation of beta-C-13 monolabelled alpha-aminoisobutyric acid. They have to be tested in the preparation of alpha-methyl amino acids like 6-[F-18]-alpha-methylDOPA and 2-[F-18]-alpha-me
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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