AN ASYMMETRIC APPROACH TO THE RADIOSYNTHESIS OF BOTH ENANTIOMERS OF alpha-[C-11]METHYLDOPA AND alpha-[C-11]METHYLTYROSINE FOR POSITRON EMISSION TOMOGRAPHY

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12640%2F06%3A00010093" target="_blank" >RIV/60076658:12640/06:00010093 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
AN ASYMMETRIC APPROACH TO THE RADIOSYNTHESIS OF BOTH ENANTIOMERS OF alpha-[C-11]METHYLDOPA AND alpha-[C-11]METHYLTYROSINE FOR POSITRON EMISSION TOMOGRAPHY
Original language description
In PET, alpha-methyl amino acids can play a dual role: a) precursors of neurotransmitters analogues for the study of neurodegenerative diseases; b) non-metabolised analogues of proteinogenic amino acids for the study of amino acids uptake into normal andcancer cells. The difference in the uptake rates during a PET scan could visualise cancer cells in a human body. Clinical applications of such amino acids are strongly limited due to their poor availability. For the synthesis of alpha-[C-11]methyltryptophan, an industrial procedure was adopted. All attempts to prepare enantiomerically pure alpha[C-11]methylated tyrosine failed. We carried out [C-11] methylation of metalocomplex synthons derived from protected DOPA or tyrosine. Individual diastereomerswere successfully separated by preparative HPLC, diluted with excess of water and extracted on C-18 cartridges. Optimisation of the procedure followed by hydrolysis of the complexes and purification of the enantiomers of alpha[C-11] methy
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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