Salicylanilide esters of N-protected amino acids as novel antimicrobial agents

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F09%3A00008372" target="_blank" >RIV/00216275:25310/09:00008372 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/09:00208920 RIV/00216208:11160/09:00210100 RIV/62157124:16370/09:00002071
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Salicylanilide esters of N-protected amino acids as novel antimicrobial agents
Original language description
A series of novel, highly antimicrobial salicylanilide esters of N-protected amino acids were synthesized and characterized. Their in vitro antimicrobial activity against eight fungal strains and Mycobacterium tuberculosis was determined. The compounds had the highest level of activity against Aspergillus fumigatus, Absidia corymbifera and Trichophyton mentagrophytes, and these levels were higher than that of the standard drug fluconazole. In addition, three compounds showed interesting antituberculosisactivity, with inhibition ranging from 89% to 99%. (S)-4-Chloro-2-(4-trifluoromethylphenylcarbamoyl)-phenyl 2-benzyloxy-carbonylamino-propionate had the highest level of both antifungal and antimycobacterial activity. The structure?activity relationships of the new compounds are discussed.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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