The thermodynamic dissociation constants of naphazoline by the regression analysis of potentiometric data

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F11%3A39883554" target="_blank" >RIV/00216275:25310/11:39883554 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2478/s11532-010-0117-9" target="_blank" >http://dx.doi.org/10.2478/s11532-010-0117-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/s11532-010-0117-9" target="_blank" >10.2478/s11532-010-0117-9</a>

Result language
angličtina
Original language name
The thermodynamic dissociation constants of naphazoline by the regression analysis of potentiometric data
Original language description
The mixed dissociation constant of naphazoline is determined at various ionic strengths I [mol dm-3] in the range of 0.01 to 0.26 and at temperatures of 25°C and 37°C using ESAB and HYPERQUAD regression analysis of the potentiometric titration data. A strategy of efficient experimentation is proposed in a protonation constant determination, followed by a computational strategy for the chemical model with a protonation constant determination. Two group parameters, L0 and HT were ill-conditioned in the model and their determination is therefore uncertain. These group parameters, L0 and HT, can significantly influence a systematic error in the estimated common parameter pKa and they always should be refined together with pKa. The thermodynamic dissociation constant pKTa was estimated by nonlinear regression of {pKa, I} data at 25°C and 37°C: for naphazoline pKTa1 = 10.41(1) and 10.13(2).
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/NS9831" target="_blank" >NS9831: Optimization of laboratory examinations in endocrinology using multivariate statistics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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