Relationships between Hepatic Stearoyl-CoA Desaturase 1 activity and mRNA Expression with Liver Fat content in Humans
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F11%3A39892033" target="_blank" >RIV/00216275:25310/11:39892033 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1152/ajpendo.00306.2010" target="_blank" >http://dx.doi.org/10.1152/ajpendo.00306.2010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1152/ajpendo.00306.2010" target="_blank" >10.1152/ajpendo.00306.2010</a>
Alternative languages
Result language
angličtina
Original language name
Relationships between Hepatic Stearoyl-CoA Desaturase 1 activity and mRNA Expression with Liver Fat content in Humans
Original language description
Stearoyl-CoA desaturase-1 (SCD1) has gained much interest as a future drug target to treat fatty liver and its consequences. However, there are few and inconsistent human data about expression and activity of this important enzyme. We investigated activity and expression of SCD1 and their relationships with liver fat (LF) content in human liver samples. Fifty subjects undergoing liver surgery were studied. SCD1 activity was estimated from the ratio of oleate (C18:1) to stearate (C18:0) within lipid subfractions. Furthermore, SCD1 mRNA expression and LF content were measured. Similarly to previous studies, we observed a strong positive correlation between LF content and the C18:1/C18:0 ratio in the combined fatty acid (FA) fractions (r = 0.96, P { 0.0001), which could be interpreted as higher SCD1 activity with increasing LF. However, hepatic SCD1 mRNA expression did not correlate with LF (r = 0.16, P = 0.13). To solve these conflicting data, we analyzed the FA composition of hepatic li
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—
Result continuities
Project
—
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Physiology: Endocrinology and Metabolism
ISSN
0193-1849
e-ISSN
—
Volume of the periodical
300
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
321-326
UT code for WoS article
000289011600008
EID of the result in the Scopus database
—