High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F12%3A39895013" target="_blank" >RIV/00216275:25310/12:39895013 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1210/jc.2012-2152" target="_blank" >http://dx.doi.org/10.1210/jc.2012-2152</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1210/jc.2012-2152" target="_blank" >10.1210/jc.2012-2152</a>

Result language
angličtina
Original language name
High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet
Original language description
Context: Increased hepatic de novo lipogenesis(DNL) in response to dietary sugar is implicated in the pathology of fatty liver. Saturated fatty acids are the product of DNL and exert lipotoxic effects that promote liver fat accumulation. Desaturation offatty acids by stearoyl-CoA desaturase 1 (SCD1) can prevent these deleterious effects. Here we investigated whether DNL and SCD1 are activated in parallel by dietary sugar and influence liver fat accumulation. Methods: In 20 healthy subjects (eight females and 12 males, aged 30.5 +/- 2.0 yr, body mass index 25.9 +/- 0.5 kg/m2) who received a 4-wk lipogenic diet supplemented with 150 g/d of monosaccharides, hepatic SCD1 activity a DNL were determined using validated fatty acid ratios (16:1n-7/16:0; 16:0/18:2n-6) in very low-density lipoprotein triglycerides. Liver fat content was measured by localized 1H-magnetic resonance spectroscopy. Results: At baseline, liver fat content was positively associated with the DNL (r=0.54, P=0.01) but no
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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