Photosynthesis-Inhibiting efficiency of 4-chloro-2-(chlorophenylcarbamoyl)phenyl alkylcarbamates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F11%3A39892415" target="_blank" >RIV/00216275:25310/11:39892415 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/11:10099479 RIV/62157124:16370/11:43870796
Result on the web
<a href="http://dx.doi.org/10.1016/j.bmcl.2011.05.118" target="_blank" >http://dx.doi.org/10.1016/j.bmcl.2011.05.118</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bmcl.2011.05.118" target="_blank" >10.1016/j.bmcl.2011.05.118</a>

Result language
angličtina
Original language name
Photosynthesis-Inhibiting efficiency of 4-chloro-2-(chlorophenylcarbamoyl)phenyl alkylcarbamates
Original language description
A series of photosynthetic electron transport (PET) inhibitors from the group of salicylanilide alkylcarbamates was investigated. The compounds were analyzed using RP-HPLC to determine lipophilicity, and their PET inhibition was determined in spinach (Spinacia oleracea L.) chloroplasts. The site of action of the studied compounds is situated at the donor site of photosystem 2 (PS 2). Compounds substituted by chlorine in C0-3 and C0-4 of the aniline ring and the optimal length of the alkyl chain pentyl-heptyl in the carbamate moiety provided the most active PET inhibitors (IC50 inhibition {10 mu mol/L). Disubstitution in C0-3,4 by chlorine caused significant PET inhibiting activity decrease. Nevertheless, for all free series of C0-3, C0-4, C0-3,4 compounds, the dependence of PET activity on lipophilicity showed to be quasiparabolic.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/NS10367" target="_blank" >NS10367: Evaluation and development of new perspective antimycobacterial drugs and prodrugs active against multidrug resistant strains</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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