Synthesis and characterization of pH-sensitive conjugate of isoniazid - methoxypoly(ethylene glycol)-b-poly(L-lysine)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F12%3A39894708" target="_blank" >RIV/00216275:25310/12:39894708 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.bmcl.2012.07.054" target="_blank" >http://dx.doi.org/10.1016/j.bmcl.2012.07.054</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bmcl.2012.07.054" target="_blank" >10.1016/j.bmcl.2012.07.054</a>

Result language
angličtina
Original language name
Synthesis and characterization of pH-sensitive conjugate of isoniazid - methoxypoly(ethylene glycol)-b-poly(L-lysine)
Original language description
The present paper deals with the preparation and characterization of a conjugate of isoniazid (INH) with the block copolymer methoxypoly(ethylene glycol)-b-poly(L-lysine) (mPEG-b-PLL). The structure of the conjugate (mPEG-b-PLL-INH) was verified by meansof H-1 NMR, GPC, infrared spectroscopy, elemental analysis and powder X-ray diffraction. The conjugate contains six L-lysine units with five INH molecules, which are attached by means of pH-sensitive amidine bond. Under in vitro conditions, the conjugate is hydrolyzed and isoniazid is released (pH 4; 37 degrees C; t(1/2) approximate to 10 h).
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
<a href="/en/project/GAP106%2F11%2F0058" target="_blank" >GAP106/11/0058: Phosgene Derivatives for Nanotechnologies</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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