New series of isoniazid hydrazones linked with electron-withdrawing substituents

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F11%3A39892451" target="_blank" >RIV/00216275:25310/11:39892451 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/11:10099512
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejmech.2011.09.054" target="_blank" >http://dx.doi.org/10.1016/j.ejmech.2011.09.054</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejmech.2011.09.054" target="_blank" >10.1016/j.ejmech.2011.09.054</a>

Result language
angličtina
Original language name
New series of isoniazid hydrazones linked with electron-withdrawing substituents
Original language description
A series of new isoniazid hydrazones was synthesized by two procedures. Most of them exhibited the same activity against Mycobacterium tuberculosis (MIC 1 mmol/L) as isoniazid (INH), better activity against Mycobacterium kansasii 325/80 (MIC 0.125-0.250mmol/L), high value of selectivity index (SI) and IC50 between 0.0218 and 0.326 mmol/L. Compound 2o with the best SI was used as a model compound for the stability test and was found to be stable at neutral pH, but under acidic conditions it slowly hydrolysed.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/NS10367" target="_blank" >NS10367: Evaluation and development of new perspective antimycobacterial drugs and prodrugs active against multidrug resistant strains</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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