Antimycobacterial and herbicidal activity of ring-substituted 1-hydroxynaphthalene-2-carboxanilides

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F13%3A43871896" target="_blank" >RIV/62157124:16170/13:43871896 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/13:43871896

Result on the web

<a href="http://dx.doi.org/10.1016/j.bmc.2013.08.030" target="_blank" >http://dx.doi.org/10.1016/j.bmc.2013.08.030</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bmc.2013.08.030" target="_blank" >10.1016/j.bmc.2013.08.030</a>

Result language

angličtina

Original language name

Antimycobacterial and herbicidal activity of ring-substituted 1-hydroxynaphthalene-2-carboxanilides

Original language description

In this study, a series of 22 ring-substituted 1-hydroxynaphthalene-2-carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against Mycobacterium marinum, Mycobacterium kansasii and Mycobacterium smegmatis. The compounds were also tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Most of tested compounds showed the antimycobacterial activity against thethree strains comparable or higher than the standard isoniazid. N-(3-Fluorophenyl)-1-hydroxynaphthalene-2-carboxamide showed the highest biological activity (MIC = 28.4 mu mol/L) against M. marinum, N-(4-fluorophenyl)-1-hydroxynaphthalene-2-carboxamideshowed the highest biological activity (MIC = 14.2 mu pi mol/L) against M. kansasii, and N-(4-bromophenyl)-1-hydroxynaphthalene-2-carboxamide expressed the highest biological activity (MIC = 46.7 mu mol/L) against M. smegmatis. This compo

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioorganic and Medicinal Chemistry

ISSN

0968-0896

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

21

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

6531-6541

UT code for WoS article

000325164500028

EID of the result in the Scopus database

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