Cerebrospinal fluid fatty acid in Glucocerebrosidase-Associated Parkinson's Disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F12%3A39895001" target="_blank" >RIV/00216275:25310/12:39895001 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Cerebrospinal fluid fatty acid in Glucocerebrosidase-Associated Parkinson's Disease
Original language description
Background: Heterozygous mutation in the glucocerebrosidase gene lead to an increased risk for and to more severe alpha-synuclein-associated pathology in Parkinson's disease. As both glucocerebrosidase and alpha-synuclein interact with fatty acids, we hypothesized that cerebrospinal fluid fatty acid level are altered in these Parkinson's patients. Methods: Cerebrospinal fluid levels of 13 fatty acids in 8 Parkinson's disease patients with a heterozygous glucocerebrosidase mutation were compared with those of 41 idiopathic Parkinson's disease patients and 30 controls using gas chromatography. Results: Parkinson's disease patients with a heterozygous glucocerebrosidase mutation had lover levels of palmitoleic acid (P= 0.007), oleic (P=0.016), linoleic (P=0.005), arachidonic (P=0.003), eicosapentaeneoic (P=0.003) and docosahexaenoic (P=0.03) acids and lower levels of total fatty acids (P=0.005) compared with both idiopathic Parkinson's disease patients and control subjects. Conclusions: T
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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