Structural Characterization of Electrochemically and in Vitro Biologically Generated Oxidation Products of Atorvastatin Using UHPLC/MS/MS

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F13%3A39896258" target="_blank" >RIV/00216275:25310/13:39896258 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/13:10190907
Result on the web
<a href="http://link.springer.com/article/10.1007/s00216-013-7133-5" target="_blank" >http://link.springer.com/article/10.1007/s00216-013-7133-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00216-013-7133-5" target="_blank" >10.1007/s00216-013-7133-5</a>

Result language
angličtina
Original language name
Structural Characterization of Electrochemically and in Vitro Biologically Generated Oxidation Products of Atorvastatin Using UHPLC/MS/MS
Original language description
Ultrahigh-performance liquid chromatography coupled with high-mass-accuracy tandem mass spectrometry (UHPLC-MS-MS) has been used for elucidation of the structures of oxidation products of atorvastatin (AT), one of the most popular commercially availabledrugs. The purpose of the study was identification of AT metabolites in rat hepatocytes and comparison with electrochemically generated oxidation products. AT was incubated with rat hepatocytes for 24 h. Electrochemical oxidation of AT was performed by use of a three-electrode off-line system with a glassy carbon working electrode. Three supporting electrolytes (0.1 mol L-1 H2SO4, 0.1 mol L-1 HCl, and 0.1 mol L-1 NaCl) were tested, and dependence on pH was also investigated. AT undergoes oxidation by asingle irreversible process at approximately +1.0 V vs. Ag/AgCl electrode. The results obtained revealed a simple and relatively fast way of determining the type of oxidation and its position, on the basis of characteristic neutral losses
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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