Reliability of Protonation Constants of Vildagliptin Dimers by the Regression Analysis of pH-Titration Data
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F13%3A39896417" target="_blank" >RIV/00216275:25310/13:39896417 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/article/10.2478%2Fs11532-013-0244-1" target="_blank" >http://link.springer.com/article/10.2478%2Fs11532-013-0244-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/s11532-013-0244-1" target="_blank" >10.2478/s11532-013-0244-1</a>
Alternative languages
Result language
angličtina
Original language name
Reliability of Protonation Constants of Vildagliptin Dimers by the Regression Analysis of pH-Titration Data
Original language description
Protonation constants of protonated monomers and dimers of the vildagliptin are determined potentiometrically. For the low concentration c (L) = 3.3 mmol dm(-3) the monomers L and LH dominate, while for a higher concentration c (L) = 6.3 mmol dm(-3) thedimers L2H2, L2H3, L2H4 and L2H are mainly present. The algorithm used has little influence on the precision of the formation constants in comparison with the reproducibility of the titration. The mixed protonation constants of vildagliptin dimers L (q)H (r) at various temperatures are determined using FBSTAC4 and HYPERQUAD regression analysis of the potentiometric titration data. The accuracy of the protonation constants log(10) beta (qr) depends on the accuracy of the group parameters. As two group parameters L (0), H (T) are ill conditioned in a model, their determination is therefore uncertain; both can significantly cause a systematic error in the estimated common parameters log(10) beta (qr) . Using various regression diagnostics
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Central European Journal of Chemistry
ISSN
1895-1066
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
7
Country of publishing house
PL - POLAND
Number of pages
11
Pages from-to
1101-1111
UT code for WoS article
000318180300008
EID of the result in the Scopus database
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