Development of LC/MS/MS Method for Determination of Acetaminophen Metabolites

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F13%3A39896543" target="_blank" >RIV/00216275:25310/13:39896543 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Development of LC/MS/MS Method for Determination of Acetaminophen Metabolites

Original language description

A liquid chromatography-tandem mass spectrometry method for the determination of two acetaminophen metabolites, i.e. acetaminophen-glutathione and acetaminophen-cysteine conjugates was developed. The octadecyl silica gel column has been used together with the gradient elution of methanol/water for fast separation of metabolites in less than four minutes. Tandem mass spectrometry in multiple reaction monitoring mode was applied for identification and quantitation of metabolites using deuterated acetaminophen as the internal standard.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

—

Project

<a href="/en/project/NT14320" target="_blank" >NT14320: Study of a new mechanism of acetaminophen toxicity in liver and possibilities of therapy</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemické listy S

ISSN

1803-2389

e-ISSN

—

Volume of the periodical

107

Issue of the periodical within the volume

s3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

3

Pages from-to

"s348"-"s350"

UT code for WoS article

—

EID of the result in the Scopus database

—