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Synthesis and antimycobacterial and photosynthesis-inhibiting evaluation of 2-[(E)-2-substituted-ethenyl]-1,3-benzoxazoles

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39898185" target="_blank" >RIV/00216275:25310/14:39898185 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11160/14:10281981 RIV/62157124:16370/14:43872695

  • Result on the web

    <a href="http://dx.doi.org/10.1155/2014/705973" target="_blank" >http://dx.doi.org/10.1155/2014/705973</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1155/2014/705973" target="_blank" >10.1155/2014/705973</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis and antimycobacterial and photosynthesis-inhibiting evaluation of 2-[(E)-2-substituted-ethenyl]-1,3-benzoxazoles

  • Original language description

    A series of twelve 2-[(E)-2-substituted-ethenyl]-1,3-benzoxazoles was designed. All the synthesized compds. were tested against three mycobacterial strains. The compds. were also evaluated for their ability to inhibit photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. 2-[(E)-2-(4-Methoxyphenyl)ethenyl]-1,3-benzoxazole, 2-[(E)-2-(2,3-dihydro-1-benzofuran-5-yl)ethenyl]-1,3-benzoxazole and 2-{(E)-2-[4-(methylsulfanyl)phenyl]ethenyl}-1,3-benzoxazole showed the highest activity against M. tuberculosis, M. kansasii, and M. avium, and they demonstrated significantly higher activity against M. avium and M. kansasii than isoniazid. The PET-inhibiting activity of the most active ortho-substituted compd. 2-[(E)-2-(2-methoxyphenyl)ethenyl]-1,3-benzoxazole was IC50 = 76.3 mýmol/L,while the PET-inhibiting activity of para-substituted compds. was significantly lower. The site of inhibitory action of tested compds. is situated on the donor side of photosystem II. T

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Scientific World Journal

  • ISSN

    1537-744X

  • e-ISSN

  • Volume of the periodical

    2014

  • Issue of the periodical within the volume

    August 2014

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    "705973-1"-"705973-11"

  • UT code for WoS article

    000343573100001

  • EID of the result in the Scopus database