Synthesis and antimycobacterial and photosynthesis-inhibiting evaluation of 2-[(E)-2-substituted-ethenyl]-1,3-benzoxazoles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39898185" target="_blank" >RIV/00216275:25310/14:39898185 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/14:10281981 RIV/62157124:16370/14:43872695
Result on the web
<a href="http://dx.doi.org/10.1155/2014/705973" target="_blank" >http://dx.doi.org/10.1155/2014/705973</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2014/705973" target="_blank" >10.1155/2014/705973</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and antimycobacterial and photosynthesis-inhibiting evaluation of 2-[(E)-2-substituted-ethenyl]-1,3-benzoxazoles
Original language description
A series of twelve 2-[(E)-2-substituted-ethenyl]-1,3-benzoxazoles was designed. All the synthesized compds. were tested against three mycobacterial strains. The compds. were also evaluated for their ability to inhibit photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. 2-[(E)-2-(4-Methoxyphenyl)ethenyl]-1,3-benzoxazole, 2-[(E)-2-(2,3-dihydro-1-benzofuran-5-yl)ethenyl]-1,3-benzoxazole and 2-{(E)-2-[4-(methylsulfanyl)phenyl]ethenyl}-1,3-benzoxazole showed the highest activity against M. tuberculosis, M. kansasii, and M. avium, and they demonstrated significantly higher activity against M. avium and M. kansasii than isoniazid. The PET-inhibiting activity of the most active ortho-substituted compd. 2-[(E)-2-(2-methoxyphenyl)ethenyl]-1,3-benzoxazole was IC50 = 76.3 mýmol/L,while the PET-inhibiting activity of para-substituted compds. was significantly lower. The site of inhibitory action of tested compds. is situated on the donor side of photosystem II. T
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific World Journal
ISSN
1537-744X
e-ISSN
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Volume of the periodical
2014
Issue of the periodical within the volume
August 2014
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
"705973-1"-"705973-11"
UT code for WoS article
000343573100001
EID of the result in the Scopus database
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