Comparison of inhibitory effects between acetaminophen-glutathione conjugate and reduced glutathione in human glutathione reductase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39898305" target="_blank" >RIV/00216275:25310/14:39898305 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jat.2914" target="_blank" >http://dx.doi.org/10.1002/jat.2914</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jat.2914" target="_blank" >10.1002/jat.2914</a>
Alternative languages
Result language
angličtina
Original language name
Comparison of inhibitory effects between acetaminophen-glutathione conjugate and reduced glutathione in human glutathione reductase
Original language description
Acetaminophen overdose is the most frequent cause of acute liver injury. The main mechanism of acetaminophen toxicity has been attributed to oxidation of acetaminophen. The type of enzyme inhibition was observed to be competitive in the cases of both APAP-SG and glutathione. As glutathione inhibits GR activity in cells under physiological conditions, the rate of enzyme inhibition ought to be weaker in the case of glutathione depletion that is typical of acetaminophen overdose. Notably, however, enzyme activity likely remains inhibited due to the presence of APAP-SG, which might enhance the pro-oxidative status in the cell.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT14320" target="_blank" >NT14320: Study of a new mechanism of acetaminophen toxicity in liver and possibilities of therapy</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Applied Toxicology
ISSN
0260-437X
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
968-973
UT code for WoS article
000340291200003
EID of the result in the Scopus database
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