Application of Human Cholinesterase in Determination of Inhibitory Effect of Salicylanilide diethyl phosphates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F15%3A39899824" target="_blank" >RIV/00216275:25310/15:39899824 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Application of Human Cholinesterase in Determination of Inhibitory Effect of Salicylanilide diethyl phosphates
Original language description
The aim of our study was in vitro determination of inhibitory effect of ten substituted salicylanilide diethyl phosphates to both of human cholinesterases. The source of enzymes was the blood which was obtained from volunteer donors. Inhibition efficiency of tested inhibitors was described by the value of IC50 (50% inhibiting concentration). Final activity of human enzymes was calculated for used reaction conditions. The concentration of substrate (acetylthiocholine and butyrylthiocholine) was 1.10-3 M.All tested inhibitors are potent inhibitors of human cholinesterases. Compound 8 ((O-{4-bromo-2-[(3,4-dichlorophenyl)carbamoyl]phenyl} O,O-diethyl thiophosphate) was the most effective inhibitor of HuAChE and the compound 3 (O-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl} O,O-diethyl thiophosphate) was the most effective inhibitor of HuBChE for both of used substrates.
Czech name
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Czech description
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
4th International Miniconference of PhD Students: When Biochemistry Meets Pharmacology and Toxicology
ISBN
978-80-971042-5-2
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
17-20
Publisher name
Ústav experimentálnej farmakológie a toxikológie SAV
Place of publication
Bratislava
Event location
Bratislava
Event date
Jun 24, 2015
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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