Diethyl 2-(Phenylcarbamoyl)phenyl Phosphorothioates: Synthesis, Antimycobacterial Activity and Cholinesterase Inhibition

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39897931" target="_blank" >RIV/00216275:25310/14:39897931 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/14:10281975

Result on the web

<a href="http://dx.doi.org/10.3390/molecules19067152" target="_blank" >http://dx.doi.org/10.3390/molecules19067152</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules19067152" target="_blank" >10.3390/molecules19067152</a>

Result language

angličtina

Original language name

Diethyl 2-(Phenylcarbamoyl)phenyl Phosphorothioates: Synthesis, Antimycobacterial Activity and Cholinesterase Inhibition

Original language description

A new series of 27 diethyl 2-(phenylcarbamoyl)phenyl phosphorothioates (thiophosphates) was synthesized, characterized by NMR, IR and CHN analyses and evaluated against Mycobacterium tuberculosis H(37)Rv, Mycobacterium avium and two strains of Mycobacterium kansasii. The best activity against M. tuberculosis was found for O-{4-bromo-2-[(3,4-dichlorophenyl)carbamoyl] phenyl} O,O-diethyl phosphorothioate (minimum inhibitory concentration of 4 mu M). The highest activity against nontuberculous mycobacteriawas exhibited by O-(5-chloro-2-{[4-(trifluoromethyl) phenyl] carbamoyl}phenyl) O, O-diethyl phosphorothioate with MIC values from 16 mu M. Prepared thiophosphates were also evaluated against acetylcholinesterase from electric eel and butyrylcholinesterase from equine serum. Their inhibitory activity was compared to that of the known cholinesterases inhibitors galanthamine and rivastigmine. All tested compounds showed a higher (for AChE inhibition) and comparable (for BChE inhibition) ac

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecules

ISSN

1420-3049

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

6

Country of publishing house

CH - SWITZERLAND

Number of pages

17

Pages from-to

7152-7168

UT code for WoS article

000338586700015

EID of the result in the Scopus database

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